Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7
نویسندگان
چکیده
منابع مشابه
Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates
Activation of toll-like receptors (TLRs) on cells of the innate immune system initiates, amplifies, and directs the antigen-specific acquired immune response. Ligands that stimulate TLRs, therefore, represent potential immune adjuvants. In this study, a potent TLR7 agonist was conjugated to phospholipids, poly(ethylene glycol) (PEG), or phospholipid-PEG via a versatile benzoic acid functional g...
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BACKGROUND Newborns and young infants are at higher risk for infections than adults, and manifest suboptimal vaccine responses, motivating a search for novel immunomodulators and/or vaccine adjuvants effective in early life. In contrast to most TLR agonists (TLRA), TLR8 agonists such as imidazoquinolines (IMQs) induce adult-level Th1-polarizing cytokine production from human neonatal cord blood...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2010
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.09.093